Takeda kenzo biography of martin

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    Blockade of CD47 signaling enhances the anti-tumor effects of intratumoral STING stimulation bygd activating monocyte/macrophage phagocytosis and tumor-specific T cells. This combination therapy induces systemic anti-tumor immune responses, which rely on STING and type inom IFN signaling.

    Abstract

    Activation of STING signaling plays an important role in anti-tumor immunity, and we previously reported the anti-tumor effects of STING through accumulation of M1-like macrophages in tumor tissue treated with a STING agonist. However, myeloid cells något som utförs snabbt exempelvis expressleverans SIRPα, an inhibitory receptor for phagocytosis, and its receptor, CD47, is overexpressed in various cancer types. Based on our findings that breast cancer patients with highly expressed CD47 have poor survival, we evaluated the therapeutic efficacy and underlying mechanisms of combination therapy with the STING ligand cGAMP and an antagonistic anti-CD47 mAb using E0771 mouse breast cancer cells. Anti-CD47 mAb monotherapy did not suppress

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    Kenzo Tange was born September 4, 1913 in Osaka, Japan. After graduating from the University of Tokyo in 1938 and working for Kunio Mayekawa, a student of Le Corbusier, Kenzo Tange won the competition for the Hiroshima Peace Center in 1949. His architectual work includes the Shizoka Press and Broadcasting Centre (1966–7), the National Gymnasium for the 1964 Olympic Games, and the theme pavilion for the 1970 Osaka Exposition. His ‘Plan for Tokyo’ received attention for its new concepts of extending the growth of the city out over the bay, using bridges, man-made islands, floating parking, and megastructures. His highly influential published works include A Plan for Tokyo (1960) and Toward a Structural Reorganization (1960). He was awarded the Pritzker Architecture Prize in 1987.

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    Kenzō Takada

    Japanese-French fashion designer (1939-2020)

    Kenzō Takada (高田 賢三, Takada Kenzō, [takada kenꜜzoː]; 27 February 1939 – 4 October 2020) was a Japanese–French fashion designer living in France. He founded Kenzo, a worldwide clothing brand, that also markets skin care and perfumes, Takada was the honorary president of the Asian Couture Federation.

    Early life

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    Takada was born on 27 February 1939 in Himeji, Hyōgo Prefecture. He was one of seven children of Kenji and Shizu Takada,[1][2] who ran a hotel.[3] His love for fashion developed at an early age, particularly through reading his sisters' magazines.[4] In 1957,[5] he briefly attended Kobe City University of Foreign Studies. However, after his father died during Takada's first year at university,[6] he withdrew from the program against his family's wishes.[4] In 1958, he enrolled at Tokyo's Bunka Fashion College, which had the

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